Processed EHR text can be used to develop CDS tools Read more: Processed EHR text can be used to develop Clinical decision support tools with automated text processing

See on Scoop.itinPharmatics

Free text in electronic health records, with the help of natural language processing (NLP) technology, can be used to create accurate clinical decision support (CDS) tools, according to a study published this week in the Journal of the American Medical Informatics Association

See on jamia.bmj.com

Why mHealth hasn’t created an Instagram (yet)

See on Scoop.itinPharmatics

Read about why a Qualcomm Life executive says mobile health doesn’t yet have an Instagram, and why it eventually will.

See on www.medcitynews.com

Microsoft Lync Pilot Aids AstraZeneca Sales Rep, Researcher Collaboration – Health Care IT – News & Reviews – eWeek.com – eWeek Mobile

Via Scoop.itinPharmatics

Biopharmaceutical vendor AstraZeneca has launched a unified communications pilot using Microsoft Lync to improve collaboration among pharmaceutical sales reps, doctors and researchers.
Via mobile.eweek.com

American Diabetes Association to provide millions of website users medication monitoring service using Quintiles’ Digital Patient Unit –

Via Scoop.itinPharmatics

 Quintiles and the American Diabetes Association announced a strategic agreement in which Quintiles’ Digital Patient Unit will provide the Association’s millions of website users access to Quintiles’ medication monitoring service.

 

The Association’s constituents who opt in for the service will receive free safety checks of their medications to identify potential interactions and other risk factors, which are already provided to the 2.5 million registered users of Quintiles’ www.MediGuard.org. Registrants will also be eligible to participate in select direct-to-patient programs to benefit their medical conditions and advance global diabetes patient care.

 

The Association’s constituents may opt in to this service from the Association’s website www.Diabetes.org

Via www.quintiles.com

Oracle acquire cloud based clinical operations and analytics vendor ClearTrial

Via Scoop.itinPharmatics

On March 29, 2012, Oracle announced that it has agreed to acquire ClearTrial, a leading provider of cloud-based Clinical Trial Operations and analytics products that make the planning, sourcing, and tracking of clinical projects and financial performance…

Via www.oracle.com

Can “Clinical Data Integration on the Cloud” be a reality?

 

The story I am about to tell is almost 8 years old. I was managing software services delivery for a global pharmaceutical company from India. This was a very strategic account and the breadth of services covered diverse systems and geographies. It is very common that staff from the customer organization visit our delivery centers (offsite locations) to perform process audits, governance reviews and to meet people in their extended organizations.

During one such visit a senior executive noticed that two of my colleagues, sitting next to each other, supported their system (two different implementations of the same software) across two different geographies. They happened to have the name of the systems they support, pinned to a board at their desks. The executive wanted us to take a picture of the two cubicles and email to him. We were quite surprised at the request. Before moving on to speak to other people he asked a couple of questions and realized the guys were sharing each other’s experiences and leveraging the lessons learnt from one deployment for the other geography.  It turned out that this does not happen in their organization, in fact their internal teams hardly communicate as they are part of different business units and geographies

Read full article on at inPharmatics

Pharma looks to mobile strategies to effectively reach prescribers | mHIMSS

Via Scoop.itinPharmatics

Companies on the forward edge are putting a heavy emphasis on digital in their commercial models — but how can mobile technologies assist pharmaceutical and biotech firms in this transition?   Tablets to support the sales force – While sales forces are shrinking, they still play a vital role in educating prescribers on new medications. The pharma industry, taking the lead of companies like GSK, is starting to incent sales reps based on quality of service versus amount of sales (read more here in the WSJ). One of the tools that is helping deliver better service is the tablet. Reps with an iPad can deliver more interactive and engaging product information, capture signatures for compliance and make the most of a few quick minutes with a doctor in the time it would take a laptop to boot up.   Online and mobile drug sampling programs – Companies now have the ability to leverage PDMA-compliant mobile apps and websites that allow physicians to request free product samples that they can distribute to their patients to gauge efficacy and assist with adherence. Because the Internet never sleeps, physicians can do this no matter what shifts they are working, independent of time zone or location, 24 hours a day.   Direct-to-HCP mobile advertising – It used to be that most online and mobile advertisements for drugs were placed only in industry magazines, blogs and online communities geared toward healthcare professionals and general consumer websites. We see this changing, with emergence of mobile networks focused on healthcare such as Tomorrow Networks, which is comprised of more than 50 medical apps. Pharma companies can now buy ad placements in mobile apps made exclusively for physicians and other healthcare professionals. A physician can be looking up treatment information at the point of care and see an ad for a medication that is relevant to their patient’s ailment. That’s incredibly powerful for the physician and advantageous for the advertiser.   mDetails – Physicians want to learn about the best drugs and treatments for their patients. mDetails are multimedia mobile product presentations that provide information about drugs in a way that allows physicians to absorb detailed information at their own pace — and in their own time. Because mDetails are distributed on smartphones – it lets physicians fit pharma product education into ‘found time’ at any point during their day that’s convenient for them.   By employing a multi-channel approach and by helping healthcare professionals do their jobs better instead of just selling to them, pharmaceutical companies can reach their target audiences and develop deeper value-based relationships. The aforementioned examples are just a few of the ways that pharmaceutical companies can leverage the ever-growing mobile channel; there are many more evolving every day.
Via www.mhimss.org

British Government launches Government Cloud Store with 257 Cloud Computing Suppliers

Via Scoop.itinPharmatics
UK Government launches G-Cloud store with 257 cloud computing suppliers. Offering the public sector around 1,700 cloud computing services for year-long contracts. The G-Cloud initiative, dubbed CloudStore, aims to bring a broader range of cloud computing suppliers to the government market and increase the flexibility in procurement contracts
Via www.govstore.net

privacy controlled social networking to connect patients with caregivers

Via Scoop.itinPharmatics
Privacy controlled & safe social network for Healthcare launched by Jonathan Schwartz, Ex-CEO Sun Microsystems. The networks available at http://www.carezone.com  Connects Caregivers With family members and allows health-care workers share information about aging or ill parents, spouses and children
Via www.bloomberg.com

SOCIAL CRM and its Impact on Pharmaceutical Industry

“The Banks Can Do It, Why Can’t Hospitals?”

Via Scoop.itinPharmatics

In other words, computing in the banking industry is perfected, so why can’t healthcare get its act together? (Irrespective of the sea change of difference between simple financial data and incredibly complex medical data.) …
Via hcrenewal.blogspot.com

One Way to Teach Your Boss About Social Media

Via Scoop.itinPharmatics

Do you want your boss to realize the full potential of social media? Yesterday on Pixels & Pills we talked about John Mack’s observation that very few senior executives attend digital pharma conferences.
Via www.pixelsandpills.com

Is Life Sciences the New Frontier for Analytics?

Via Scoop.itinPharmatics

pharmaceuticals Researchers say pharmaceutical and other life sciences companies are ramping up their uses of analytics…
Via smartdatacollective.com

Internet on any Display Device, or internet on TV at low cost can it transform Healthcare or Clinical Research

The invention of an internet set top box has nothing to do with healthcare or  clinical trial at first look. But if HP and other companies are capable of delivering the research, then internet on any display device could change the way clinical trial is practiced at-least beginning with EDC. Yes I agree it is bit far fetched wild thought, but why not. It can also perhaps bring some transformation into patient waiting rooms in hospitals. HP’s invention along with Microsoft Kinect for PC is capable of bringing some big changes to healthcare  practice, mostly notably in TeleHealth.

If nothing else it would atleast bring internet to the masses much faster and cheaper than Android, 3G, and LTE, WiMax all put together, for the simple reason that most of the households that are capable of benefiting from the internet has access to TV as well. atleast in India

Take a look at news coverage ” HP India Research Labs brings Internet TV for the masses with the help of a TV set top box that cost less than $150″ news by Times of India

HP Labs has recently came out with what they call as “Internet TV Set Top Box for the masses” the product is called  Vayu Internet Device or VInD. HP Labs India has created the product which was reviewed by Times of India News paper. The solution enables people to receive internet content on even the most basic TV sets and manage all screen operations using basic TV remotes.

More About HP Labs Vayu Experience Platform

The HP product offers the following solutions,

Task Genie: This is a store of  apps, Yes apple has tons of them , but how many of them are useful , and several of those apps are me too products. Before anyone shouts shoot him let me tell you I have an iPhone4 loaded with 319 apps, I don’t think any one can beat that, and yet I don’t use almost 300 of them at-least once in a month, despite the fact that except one or 2 games most  other are serious apps. Yes I agree among the 300 are several apps which are me too copy cat apps which offers same function, like contact management and duplicate remover, SMS apps, chat solutions. The point is more the apps the better is not true, its the quality that matters that’s were Android fails

Web Tuner: This allows the user to create web categories, such as say News or Tech or Nature, and within each he can have the particular websites he is most interested in

Libraries: allows users to store photos, videos, music and documents in the set-top box’s hard disk. Users can tag and share them with others who have similar set-top boxes.

Contacts and Whiteboard: Users can create and store a contacts list. They can share content or have a video-conference with others who have similar set-top boxes.

Pairing with mobile phone: The set-top box can be paired with mobile phones. So, if it is paired with the user’s phone,he  can send messages to his  TV

Sensor: VInD comes with a built-in Zigbee sensor network. VInD detects the motion and sends an alert to the paired phone.

Keyboard and mouse: Vayu, which uses aLinux  operating system, can also be used as a regular PC, with a keyboard and mouse with a browser and with the TV acting as the monitor. It can be a wired or a wireless keyboard and mouse. This is were I think ViND can bring some advantage in clinical research space, every clinical trial monitoring room has  a TV

Tech Specs#: VInD has 1 GB of built-in RAM, 8GB of flash memory and the ability to add an additional 300 GB hard-disk. It comes with built-in Zigbee sensor network, USB ports, Wi-Fi, ethernet and Bluetooth 2.1 and infrared connectivity. It connects to the TV via HDMI and regular AV channel ports. It also supports GPRS, 3G and HSDPA through the use of a USB modem. It has in-built microphone and speakers and a display

Microsoft has released the Kinect for PC. It was reported that Microsoft is keen to see kinect taking an active part in Healthcare industry. Doctors are using Kinect to help stroke patients regain movement full St0ry Here. Then later there was news that Microsoft and Asus have built a laptop with Kinect motion-sensing technology.

Of-course HP is not the first to come out with this kind of  technology,

 most of the existing expensive solutions are not  comprehensive and too focused on living room with limited or no net browsing capability.

iChip Technolgies has announced their solution called @Box which claimed to bring internet to any display device including even the office projector. @Box is smaller than palm and would be sold in standard package with a key board, track ball, power adaptor and a cable to connect to the TV and would cost less than $100

iChip Technologies which was based in India was later acquired by Techfarm Ventures US-based incubator and early stage investor in technology companies. Gordon Campbell, Chief Executive Officer of Techfarm, is also the CEO and Co-founder of Personal Web (PW) Systems, a company incorporated in the US.

Techfarm Ventures had earlier invested in PortalPlayer, which went in for an IPO in 2004, and subsequently got bought out by nVIDIA in January 2007. Techfarm has earlier incubated more than a dozen companies such as the first Ethernet chip and graphics controller

Neuros Technology produces a similar product that works on Ubuntu platform called Neuros LINK, which seems to be more closer to the HP solution

Logitech and Google has released Revue a solution based on Android

Apple is talking about Apple TV for sometime

UK based Telecom operator Vodafone has launched Webbox a product that seems to draw power from Vodafones EDGE/GSM/3G network using Opera Mini Browser

Oracle Unveils Oracle® Health Sciences Omics Data Bank as Part of Oracle Health Sciences Translational Research Center

Via Scoop.itinPharmatics

Oracle Exadata gets into Personlized Medicine & Bioinformatics space dressed as Oracle® Health Sciences Omics Data Bank.    Oracle Health Sciences today announced availability of Oracle® Health Sciences Omics Data Bank, a molecular data model, which is part of Oracle Health Sciences Translational Research Center.   The new data model provides integration and analysis of cross-platform omics data to support translational research. Oracle Health Sciences Translational Research Center runs on Oracle Exadata Database Machine, delivering the extreme performance required for querying vast data sets.
Via www.oracle.com

Drug Reps Soften Their Sales Pitches, as pharma learns from Disney

Via Scoop.itinPharma

Drug makers are now asking their sales representatives to switch from making forceful, tightly scripted sales pitches to acting more like a resource supporting physicians’ treatment.
Via online.wsj.com

Indian Government’s new dose of strong medicine to bring cheers to Foreign Pharma CEOs who cut their teeth by struggling to convince Indian pharma to change sales practices

Good news for all Foreign CEOs of Global Pharma’s who left India after learning that, in India drug sales are driven by Freebies, and no one would listen to their advice to mend sales practices and unethical marketing practices.

Indian Government issues a strong dose of medicine . The new norms to hold pharma MDs, CEOs responsible for offering freebies to doc.

Under new guidelines drug firms will be barred from offering freebies to doctors — free travel tickets, hotel stay, gifts and hospitality, and the like. If any drug firm is found violating these guidelines, the responsibility would lie squarely with the MD and CEO of the respective company.

Further, the drug firms concerned may be prohibited from using brand names of competitive products in their promotional activities trying to claim superiority for its products.

The new guidelines would also prohibit drug firms to get doctors to endorse their products both online and offline

 

Questions for the CRO

IBM Files Application to Patent The Patent

Ever heard of people getting obnoxious amount of money to conduct research or get a PhD for pointless research. Thats what came to my mind when I first came across this news from IBM.

Just remind these were some of the winning ideas that funded by Government in US for Research papers and PhDs

1. the National Science Foundation once gave $100K grant to research why American players go to greater lengths to mod the popular MMO than do Chinese WoW players.

2.  Pressures Produced When Penguins Pooh — Calculations on Avian Defaecation”, Polar Biology, 2004

3. Suicide rates are linked to the amount of country music played on the radio, , Medicine, 2005

4. Rats can’t always tell the difference between Japanese spoken backwards and Dutch spoken backwards, winner, Linguistics, 2007

 As much as I stand to loose a chance to get a job at IBM by this post, its  so hard not to think loud, and ask IBM what the heck was wrong with your brains, when you made the decision to patent the patent.

 The Original Post Pasted from http://www.tomshardware.com/news/ibm-patents-the-patent,11868.html

IBM Files Application to Patent The Patent Process

6:40 PM – January 3, 2011 by Douglas Perry – source: ConceivablyTech
   Reading through IT patents these days requires patience and tolerance. When you can patent common sense, there is clearly something wrong with the system. But as long as no changes are being made, you are inviting people to exploit what is available and IBM has just demonstrated what may be possible, if one of their most recent patent applications is accepted by the USPTO.

The company felt it would be beneficial to patent the patent strategy process all the way from training inventors, to competitor monitoring and protecting (i.e. suing someone) a patent from infringement. This patent does not describe anything new, but a strategy that is being pursued by anyone who owns a patent and especially patent trolls or people like Paul Allen, who is just taking another shot at suing Google for patent infringement.

The patent application could mean that IBM in fact is working on a software that automates patent management or the company simply felt it was necessary to patent the idea of filing a patent and treating it in the way it could be considered common sense. It is especially revealing how much focus the inventor put on a “defend” module that implies a lawsuit strategy. It would take a genius to figure that out.   

Reading through this patent is a good lecture how a patent these days should not look like. IBM is the natural place for this idea as there is no other company that files for as many patents (and receives as many patents) as IBM does. But if the patent idea gets approved

Widespread fraud in the Clinical Trial of Drugs is pervasive event in United States

There have been several cases where Fraud in clinical trial has questioned the  Integrity of Data and ethics , when conducting clinical trial in India, which have been used by crusaders against outsourcing. But the new evidence suggest that the clinical trial fraud is more prevalent even in US. The most recent being MannKind Corporation Accused of Covering Up Adverse Clinical Trial Results

India’s poor history on adhering to patents, strong legal system, and the image of corruption means, any fraud in conducting clinical trial in India will invite serious punishment from FDA and western world. Yes we can cry that we will be singled out , or we can take necessary steps to avoid incidents such as above

MNC pharma MannKind is accused of Data Fraud Coverup  in securing FDA approval for Afrezza the inhaled insulin drug. A senior manager uncovered unlawful clinical trial conduct pertaining to the company’s Afrezza inhalant insulin device.  John Arditi, who was MannKind’s senior director of worldwide regulatory affairs, filed a wrongful termination lawsuit against his former employer, in New Jersey Superior Court, claiming he was unfairly fired by MannKind after internal audits he conducted in November 2009 uncovered “potential fraud and scientific misconduct” involving Afrezza clinical trial data

Arditi discovered discrepancies in data at both a Russian and Bulgarian trial site, according to his lawsuit.  For several months, Adverse event results were either not being recorded properly, or were fabricated to favor the approval of Afrezza.  Arditi’s lawsuit asserts that he informed superiors at MannKind, on November 9, 2009, of his adverse findings and encouraged the company to approach the U.S. Food and Drug Administration (FDA) but MannKind did not contact the agency because negative information would delay approval of the New Drug Application (NDA) for Afrezza.

The new revelation on MannKind Afrezza Clinical Trial that emerged last week , comes just days after the report published by The Council for Clinical Research Subject Safety & Data Integrity (CCRSSDI)  on widespread fraud in the Clinical Trial drugs by pharma and CROs in Unites States.

Two time Emmy winning reporter Kathy McDevitt led an investigative team from The Council for Clinical Research Subject Safety & Data Integrity (CCRSSDI), to record Subjects committing fraud. Her investigation led to on-air confessions by two such subjects on the nature and the extent of the fraud in the industry

Ms. McDevitt and CCRSSDI have jointly released a documentary tilted “Pervasive Fraud in the Clinical Trial World” . It is available on the CCRSSDI website. Copies of the DVD may also be requested by the video.

Among the findings in the documentary:

  • Multiple simultaneous trial enrollments by Subjects
  • Inability of research sites to check for dual clinical trial enrollments
  • No single record of all the studies a subject has taken
  • Inability to verify amount of actual drug usage by a Subject in a Study
  • Potential for flawed results in Studies

Watch the Documentary on YouTube

“I was shocked by how lax the identification process is for potential Study Subjects”, said Kathy McDevitt. “I always had assumed that a thorough identification and verification was required to enroll qualified patients in studies for drugs that you and I take”

Kerri Weingard, the Director of CCRSSDI, further adds “We here at the Council have consistently raised this issue. Many members of this Council run their own Study Sites and we have seen the level of fraud increase year after year. Unfortunately, no steps are being taken by the industry as a whole to combat this problem. If this problem is left unchecked, the whole industry will suffer and public confidence in our Drug Testing process will be fundamentally undermined”

CCRSSDI has led the charge on this issue. Its charter clearly defines that the primary goal of CCRSSDI is to ensure that every study by every site and every sponsor utilizes and identification and verification process to ensure that there is no fraud occurring and that subjects are not dual-enrolled or have been expelled from previous studies.

Download the explosive documentary “Pervasive Fraud in the Clinical Trial World”, at www.CouncilForClinicalResearch.com

For further information please contact Kerri Weingard, Director, Council for Clinical Research Subject Safety & Data Integrity at KWeingard(at)CouncilForClinicalResearch(dot)com or 646-225-6624

Council for Clinical Research Subject Safety & Data Integrity is composed of established members of the medical profession. Its goal is to ensure that our testing process for Clinical Research Trials remains error free and that Subject Safety is always assured. meetings are open to all. For further information please email  at info@CouncilForClinicalResearch.com.
ONE of Australia’s most senior cancer specialists has accused pharmaceutical companies of manipulating some clinical trials of medicines for commercial reasons, including deliberately delaying the release of negative findings and being reluctant to fund research into the toxicity of their drugs.  More details

Professor Stephen Clarke, who has conducted clinical trials involving humans for 15 years, agreed to speak publicly for the first time because he said it was essential for governments to fund trials of great public importance rather than leaving critical research solely to drug companies.

A number of researchers who spoke to The Age agreed, saying commercial decisions meant the public did not always get the full picture about a drug’s usefulness and safety.

Other more high profile clinical trial related issues in recent past are PPD Inc responsibility in Ketek Trial for Aventis

The FDA found the fraud 2002 in a trial supervised by PPD, the doctor was indicted 2003, convicted 2004 and Ketek was approved 2004 by the FDA using the faulty data. It wasn’t until early 2006 that liver problems in patients using Ketek came to light and subsequently, the continued reliance on the fraudulent data. Congressional hearings were called for in 2006 which were held 2007 and again 2008 when Fred Eshelman, founder of PPD testified

The FDA and drug maker Aventis were directly faulted. Eshelman washed his hands. . This clip is one of three showing Fred Eshelman’s verbal responses to questions.

Some of the other high profile cases are

News that Schering-Plough, one of the largest drug companies in the world, has been outright bribing physicians to prescribe drugs and operate sham clinical trials http://www.naturalnews.com/001298.html

University of California findings in the October issue of the Annals of Internal Medicine, that 167 placebo-controlled trials published in peer-reviewed medical journals in 2008 and 2009 and found that 92 percent of those trials never even described the ingredients of their placebo pills.

The Utah Attorney General has filed a lawsuit charging GlaxoSmithKline illegally marketed its controversial Avandia diabetes pill as a new “wonder drug” that would reduce cardiovascular risks for diabetes, but instead increased the possibility of heart attacks. Consequently, the AG alleges Glaxo hoodwinked the state Medicaid program out of $7.8 million, which is the amount Utah spent to purchase Avandia between Jan. 1, 2001 and June 30, 2010

The more recent events in India were

Glenmark Pharmaceuticals and Omnicare have closed a clinical trial site in India operated by the contract research organisation (CRO) amid accusations that an investigator acted fraudulently.

Clinical Trial Fraud – How to Identify and Steps to Handle If Found, events like these makes adherence to GCP and training of CRA, and all stake holders in clinical trial more and more important

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