About Me

Hello

Welcome to Clinical Research Clinical Trial and Pharmacogenomics Blog by Albin Paul

I Started this blog in 2005 as Microarray Blog  I am a pharmacologist by profession and is interested in science and technology and I look forward to use this blog as a place to talk about my interests in science. And what I learn in my profession in the field of drug discovery and development and bioinformatics use of IT  in Clinical Research , Drug Development and Practice of Medicine . I have started this blog bu focusing on the use of microarray technology in bioinformatics and genomics hence the name microarray blog. But as I have gained more experience I decided to expand the number topics covered , while retaining the blog name. Outside the lab Microarrays can be used in cancer therapy management, transgenomics and Genetically engineered products screening, biodefense, Mutation studies, Genetics expression studies, Study of drug resistant bacteria, pharmacogenomis, Theranostics the opportunities and advantages are many and so are the challenges

In this blog you will find information and news about use of Information Technology  in Clinical research, Drug Discovery and Drug Development, Medical * Healthcare Communication, Pharmacetical Sales & Marketing,  Pharmacoeconomics, Pharmacogenomics, clinical diagnostics, . I also write about the sue of social media and collaborative tools and its influence and benefits in the lifescience Industry

I have a special interest in all things Social Media and Networking. Keeping abreast of the latest developments in the world of Social Media, and its use in Business especially in Sales & Marketing in Lifescience and Healthcare industry by following appropriate people and content e.g. using Twitter, Facebook, LinkedIn, Digg, Technorati and writing my own blogs

Albin Paul Xavier

contact me at

Connect with me at Linkedin: http://uk.linkedin.com/in/albinpaul

Follow Me on Twitter: http://twitter.com/ClinicalSearch

9 Responses

  1. I really enjoy visiting your site. I have started something similar , but more specific in certain aspects of bioinformatics. I am astounded by the quality of scientists of your country and their ability to adopt new technologies. Certainly your countries model should be sought after by my country Greece.

  2. Hi,
    landed here,from google on a search on Vinca rosea. do u have any idea/reference abt the toxic alkaloids in vinca? do they have some?? waiting for a reply.
    best regards,
    sabitha.

  3. (Vinca rosea )
    atharanthus roseus (Madagascar Periwinkle) is a species of Catharanthus native and endemic to Madagascar. Synonyms include Vinca rosea (the basionym), Ammocallis rosea, and Lochnera rosea; other English names occasionally used include Cape Periwinkle, Rose Periwinkle, Rosy Periwinkle, and “Old-maid”.[1][2]

    In the wild, it is an endangered plant; the main cause of decline is habitat destruction by slash and burn agriculture.[3] It is also however widely cultivated and is naturalised in subtropical and tropical areas of the world.[4]

    It is an evergreen subshrub or herbaceous plant growing to 1 m tall. The leaves are oval to oblong, 2.5–9 cm long and 1–3.5 cm broad, glossy green, hairless, with a pale midrib and a short petiole 1–1.8 cm long; they are arranged in opposite pairs. The flowers are white to dark pink with a darker red centre, with a basal tube 2.5-3 cm long and a corolla 2–5 cm diameter with five petal-like lobes. The fruit is a pair of follicles 2–4 cm long and 3 mm broad.[5][6][4][7]

  4. VINRITINE IS

  5. VINCRISTINE IS USED IN CANCER AS CHEMOTHERAPY………

  6. VINCRISTINE (ALKALOIDS) IS USED IN CANCER AS CHEMOTHERAPY

  7. Albin,

    I am very interested in learning more about the use of microarrays in clinical design and drug development. However, I can not help but think that there are a large number of disadvantages associated with this new technology and their use especially in psychiatric diseases. Would you have any comments on the disadvantages of this technology as it may be used for diagnosis or judging efficacy in spectrum disorders? Would you know of a source to find this information?

    Many thanks,
    Jorge

  8. Hi Albin, et.al.

    After some background is a question.

    My company is a vendor in the area of clinical molecular diagnostics. We use low density arrays to assay only clinically relevant SNPs for various application families. They are absolutely not research oriented as are the higher density array solutions. The families of chips are Pharmacogenomics, Oncology, Infectious Disease, and Genetic Disease. Our instrument is FDA cleared, as are some very significant assays such as Warfarin dosing and Factors testing.

    Today’s clinic is justifiably far more oriented toward what tests can be reimbursed; an assay with 10,000+ data points is massive overkill. That said, I’ve had a DEVIL of a time, principally in the Seattle area, navigating the obfuscations of “Personalized Medicine” along with the politics of the UW and of Swedish Hospital. Geographic regions such as Hawaii, Western Oregon, and Fresno are, in my experience, far ahead of our region in terms of the practical implementation of economic molecular testing and “personalized medicine” which is not dependent upon the “cheap labor” of teaching universities. They are clearly not “smarter”, yet seem to understand the tidal wave which approaches. Yet still I struggle to convince university clinical leaders here that labor is actually a cost; that genomic mediated dosing for warfarin and other drugs is not the future- it’s here, so says the FDA. It’s heartbreaking to me watching Johns Hopkins, Harvard Partners, VAs throughout the East and Southeast, Children’s Hospitals in the Midwest, and many hospitals internationally moving so wisely forward, while the fiefdoms and “homebrews” of the Pacific Northwest continue to entrench.

    My question is: how can I cut through the noise (metaphorically speaking) to find regional visionaries who can implement automated, efficient clinical molecular diagnostics to immediately benefit patients?

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