Affymetrix microarrays in mental retardation research

Affymetrix is collaborating with the University of Nijmegen in the Netherlands, the University of Tuebingen in Germany and the NHS Regional Genetics Laboratory in Birmingham, U.K. for the European Cytogenetic Research Initiative to investigate causes of mental retardation,

microarray technology will be used to try to identify the specific causative mutations in mentally retarded children.

Currently, cytogeneticists use karyotyping and FISH technologies to study deletions, amplifications and other chromosomal rearrangements..

The company is also a particpant of the Encode consortium that studies the junk DNA. http://www.affymetrix.com/corporate/events/2007_7_encode.affx

Advertisements

Indian genetic database offers R&D advances

Imagine a diabetic patient from NewYork being put on a drug regimen distinct from a patient London. Personalized medicine allows tratement to decided on the genetic make up of the individual. Genetically europeans and asians and others have different ways of responding to same treatment genetically

FortunatelyIf Indian researchers have their way, such customised medication based on genetic differences could be a possibility for a range of illnesses.

A consortium of Indian scientists recently completed a genetic database for India, home to one of the world’s most ethnically diverse populations that will allow researchers to understand the genetic predisposition of ethnic groups to diseases. Icelanders are considered for Human genome project because of very less number such diversity

The genetic map will enable global and Indian pharma companies to enhance research on predictive medicine and targeted drugs. Research firm TCG Life Sciences is about to become the first private player to use the database.

The consortium collected data on the genetic codes of over a 1,000 genes from among 15,000 individuals belonging to Indian sub-populations

Another user of the data is the clinical diabetics’ consortium, which aims to identify if there are specific genetic reasons for a particular ethnic group to be predisposed to the disease. It is already known that some cultures are pre disposed to certain diseases so Indian are more prone to heart attack and diabetes and such

The Indian Genome Variation Consortium, a public-private partnership that networks six Council of Indian Scientific and Industrial Research labs and some private software firms, undertook the genetic variation mapping.

UK is appealing for volunteers to help worlds biggest medical experiment project- to understand impact of Genetics and life style in illness and medical treatment

 UK is appealing for volunteers to help worlds biggest medical experiment project- to understand impact of Genetics and lifestyle in health and medical treatment

The  BBC reports about a medical experiment aiming to be the biggest in the world is appealing for volunteers to help end Scotland’s reputation as the “sick man of Europe”.

The project named as  UK Biobank will be the world’s biggest resource for the study of the role of nature and nurture in health and disease.

Funded and guided under the supervision of leading scientists from the UK and around the world. Funded by the  Wellcome Trust, the UK’s largest independent medical research charity, the  Medical Research Council, the Department of Health, the Scottish Executive and the Northwest Regional Development Agency. and many other major medical research charities, including the British Heart Foundation and Cancer Research UK. The project is also supported by the National Health Service.

claiming to help not just the volunteer, but for the future generation to come the £61m UK Biobank project will track the health of thousands of people for up to 30 years.

Information and DNA gathered from volunteers will be used by researchers to help tackle serious diseases.

Volunteers will be asked to attend an assessment centre where they will fill out a lifestyle questionnaire, have body measurements such as bone density, blood pressure, height and weight recorded, and donate a small sample of blood and urine for long-term storage as a resource for researchers in the future.

Researchers will study the relationship between our genes, our lifestyles and our current health to find out why some people develop certain illnesses and others do not.

It is hoped the project will eventually include 500,000 volunteers from across Britain, making it the biggest study of its type ever undertaken.

The Biobank will run alongside the complementary Generation Scotland project, which focuses on how genes inherited from our parents affect the likelihood of developing diseases.

Data collected by the two projects will be used to help prevent and develop new treatments for cancer, heart disease, diabetes, Parkinson’s, Alzheimer’s, mental health illnesses, osteoporosis and arthritis.

DNA DATABASE TO HELP IDENTIFY DISAPPEARED

(May 23, 2007) The head of Chile’s Medical Legal Service (SML), Patricio Bustos, announced this week that his organization would create a DNA database that will be used to help identify the remains of those who were disappeared and murdered during the military regime led by Gen. Augusto Pinochet.

Source Santigao times

%d bloggers like this: