Affymetrix expands into personalized medicine The next big thing

Affymetrix expands into personalized medicine! Why because The next big thing in health care? is You the individual

personalized medicine is the place step every one wants to be. Roche recently went after Nimblegen for a small foothold in this developing ssicne field, Now its the turn of Affymetrix the leader in microarray DNA chips.

The company is trying to get ahead of the market curve by partnering with drug companies that are making precisely targeted medicines, tailored for patients who have specific gene variations

the company opened the Affymetrix Clinical Services Laboratory to analyze the genes in blood and saliva samples for pharmaceutical companies, diagnostic laboratory businesses and hospitals

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Tougher times for Drug Resistant Bacteria

The Secret of how to prevent bacteria from developing drug resistance has been revealed in a new study.Drugs called bisphosphonates, widely prescribed for bone loss has been found to help in preventing an enzyme that helps in conjugation of bacteria, by help of which it derives drug resistance.

Many highly-drug resistant bacteria rely on an enzyme, called DNA relaxase, to obtain and pass on their resistance genes. Relaxase  plays a crucial role in conjugation as it is the gate keeper that starts and stops the movement of DNA between bacteria durig conjugation.

researchers at the University of North Carolina at Chapel Hill, have stopped the microbes’ ability to spread, among other advantageous mutations, resistance to antibiotics, by disabling the enzyme using molecules known as  bisphosphonates

The study by Matthew Redinbo and his associates is published in this week’s Proceedings of the National Academy of Sciences USA

The antibiotic-resistant Escherichia coli bacteria that were trying to pass their genes along, actually died when their DNA relaxase was shielded thus preveinting the spread of drug resistant bacteria andpossibility of more mutations.

The news is will bring fresh hopes at a stage when drugresistant strain of the bacteria Staphylococcus aureus infects over 1 million US hospital patients every year.

Genetics and Business

I have been busy lately but found some time to go through an interesting story and a good article published in scientist magazine

  1. Father-in-law of now-infamous extensively drug-resistant TB patient studies tuberculosis at the CDC, and is now under review by the agency
  2. Genotyping with PCR -How to choose the right approach

I am working on an article about consolidation in Microarray and Bioinformatics industry so interesting to know about GenoLogics Announces Bioinformatics Partnership with Illumina  so is the  news of Roche acquiring Nimblgen and the end of patent wars with Affymetrix, Roche has also acquired 454 life sciences, It seems Roche plans to get inot clinical genomcis and theranostics application industry, the company already has FDA approved amplichip CYP450 arrays for clinical diagnostics

With many other acquisitions in the last one year  and many more in the pipeline it seems paydays for early starters.

Rribozymes prevent the spread of HIV in the body

considered by some to be the ‘living fossils’ of a time when life was based on RNA -Rribozymes have been used by researchers to prevent the spread of HIV in the body

The Medical Marketing International Group (MMI) scientists have used these ancient RNA catalysts to suppress key receptors that allow HIV to enter cells

HIV enters cells using the cellular receptors CCR5 or CXCR4 and previous work has shown that preventing the expression of these receptors using the Company’s proprietary ribozymes, which target the messenger RNA (‘mRNA’) that encodes these proteins, is highly effective at preventing HIV replication in vitro. The results announced today show that the ribozyme technology can effectively deliver the ribozyme and suppress expression of these receptors in an advanced in vivo model. Moreover, a single administration of the ribozymes was able to maintain suppression of the receptors for a significant period (>35 days so far), indicating that a pool of HIV-resistant cells could be established.

UK is appealing for volunteers to help worlds biggest medical experiment project- to understand impact of Genetics and life style in illness and medical treatment

 UK is appealing for volunteers to help worlds biggest medical experiment project- to understand impact of Genetics and lifestyle in health and medical treatment

The  BBC reports about a medical experiment aiming to be the biggest in the world is appealing for volunteers to help end Scotland’s reputation as the “sick man of Europe”.

The project named as  UK Biobank will be the world’s biggest resource for the study of the role of nature and nurture in health and disease.

Funded and guided under the supervision of leading scientists from the UK and around the world. Funded by the  Wellcome Trust, the UK’s largest independent medical research charity, the  Medical Research Council, the Department of Health, the Scottish Executive and the Northwest Regional Development Agency. and many other major medical research charities, including the British Heart Foundation and Cancer Research UK. The project is also supported by the National Health Service.

claiming to help not just the volunteer, but for the future generation to come the £61m UK Biobank project will track the health of thousands of people for up to 30 years.

Information and DNA gathered from volunteers will be used by researchers to help tackle serious diseases.

Volunteers will be asked to attend an assessment centre where they will fill out a lifestyle questionnaire, have body measurements such as bone density, blood pressure, height and weight recorded, and donate a small sample of blood and urine for long-term storage as a resource for researchers in the future.

Researchers will study the relationship between our genes, our lifestyles and our current health to find out why some people develop certain illnesses and others do not.

It is hoped the project will eventually include 500,000 volunteers from across Britain, making it the biggest study of its type ever undertaken.

The Biobank will run alongside the complementary Generation Scotland project, which focuses on how genes inherited from our parents affect the likelihood of developing diseases.

Data collected by the two projects will be used to help prevent and develop new treatments for cancer, heart disease, diabetes, Parkinson’s, Alzheimer’s, mental health illnesses, osteoporosis and arthritis.

12 DNA tests that Could Change Your Life-selected by Forbes

The complete list is published at forbes website

  • Breast Cancer
  • Adult-Onset Diabetes
  • Obesity
  • Drug Metabolism
  • Crohn’s Disease
  • Prostate Cancer
  • Duchenne Muscular Dystrophy
  • Rett Syndrome
  • Macular Degeneration
  • Alzheimer’s Disease
  • Heart Attack

Gene Testing:

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Free DNA Paternity Test for Father’s Day

I am not promoting anything here but I thought it was an intersting news aswell as nothing short of odd considering the recent and ongoing news pages spend on discussing hollywood and famous fatherhood battles inside and out of court this is  one kind of an offer that Chromosomal Laboratories, Inc. a leading DNA testing laboratory, has announced that it will repeat its  offer of five free paternity tests, a $2000 value, to fathers and alleged fathers as a special promotion to celebrate the upcoming Father’s Day holiday. Interested parties should contact Chromosomal Laboratories by June 14th to be entered into the drawing. Five fathers will be chosen at random to receive a free home paternity test kit.

source webwire

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