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Shorter Path to drug Discovery share research on failed compounds between companies the new MIT lead approach-
The moment I learned about this new project started by MIT, I could think of only one thing, I want to be part of it. The Massachusetts Institute of Technology, have, started a pharmaceutical innovation program to help drug companies adapt some successful approaches now used in aeronautics, like lean management and information-sharing among rivals.
The M.I.T. initiative, called NEW Drug Development ParadIGmS or NEWDIGs has garnered the support of
- Bayer Healthcare
- Brookings Institution
- Centers for Disease Control and Prevention (CDC)
- Eli Lilly and Company
- U.S. Food and Drug Administration (FDA)
- Johnson & Johnson
- Medco Health Solutions Inc.
- Pfizer Inc.
- Quintiles Transnational Corp.
- Vertex Pharmaceuticals Inc.
- WellPoint Inc.
One short-term goal is to identify, and rectify, the root causes of bottlenecks in the existing system. Longer term, the ambition is to create new prediction models, new ways to share information about the biology of diseases, and a new inclusiveness involving earlier participation of regulators, health insurers, health care providers and patients.
So How do they plan to change the way we conduct drug discovery and developement?
1. share information about compounds they have tried and shelved, for reasons like toxicity or inefficacy.
Results of clinical trials are availale online for free, whether or not they succeed. But no pharma company talks about projects that fail at an earlier stage. A result is that companiesother waste many millions going down experimental paths that their competitors have already tried and failed.
A visual Path of the changes suggested in the Enterprise Transformation is shows here , the document can be downloaded from the MIT website
Filed under: clinical research, digital DNA, drug development, drug discoverry, Next Generation Drug Development, Next Generation Drug Discovery, open access database | Tagged: health sciences global business unit, Oracle health sciences global business unit | 2 Comments »
Succeeding at open-source innovation: An interview with Mozilla’s Mitchell Baker and the USD $34 million Indian Government plan for Opensource Drug Development
Benjamin Franklin said “As we enjoy great advantages from the inventions of others we should be glad of an opportunity to serve others by any invention of ours; and this we should do freely and generously.” – Any one listening !
Leaders and veterans in Biotechnology and Health care research industry may not be welcoming open source ideals. But IT industry has set new benchmarks and proved that open source brings in much needed new ideas and innovation. So hear out loud from none other than chairman and former CEO of Mozilla. The article is published for free at the Mckinsey quarterly
Mitchell comments that Mozilla’s real contribution isn’t just the browser but the model of participation.
In 2005 annual report on Association of American Medical Colleges acknowledged that industry, academic and government researchers can and must work together to remove scientific hurdles in drug development.
For hte uninitaited a look at the article published in Nature Magazine in 2006 with help from Pharma major Eli Lilly-Open source R&D and collaborative drug discovery and other related blogs MnDoci FuturePundit
And don’t think these are just rants of an overenthusiastic researchers, who doesn’t know the dynamics of business, why because Director-General of the Council for Scientific and Industrial Research (CSIR) in, India unveiled a USD $34 million plan for Open Source Drug Discovery. CSIR is one of the world’s largest publicly funded R&D organisations 38 laboratories working on a range of subjects from molecular biology to road research to Himalayan bio-resources. The Council has more than 4,000 scientists working for it at these 38 labs.
The January 18 2008 meeting in NewDelhi in India was organized by Knowledge Commons, Delhi Science Forum, IIT Delhi, Red Hat and Sun on Free and Open Source model of knowledge. The highlight of the event was opensource drug development — make sure you read the Opensource India blog by Venkatesh
CSIR’s chief Sameer K. Brahmachari says, he looks for “taare zameen par” (stars on earth, a reference to one of Bollywood’s latest blockbusters), in large numbers
OSDD has the support of Sun Microsystems Inc. Hewlett-Packard, IIT Delhi, Red Hat and Indian corporate houses like TCG Life Sciences.
“Great discoveries and improvements invariably involve the cooperation of many minds. I may be given credit for having blazed the trail, but when I look at the subsequent developments I feel the credit is due to others rather than myself.’
The truth behind the new bill signed into law by President Bush on 26 December 2007, which states that the findings of NIH-funded research must be made freely available to the public within one year of publication.
But all is not Hunky dory , as more obvious once you go through the complete text of the LAW as published in Government website
And it clearly states that copyright law takes precedence over deposition into PubMed Central.
What does that mean, when you publish a research paper it usually belongs to the University or the institution that funded the project. ie if you did sign a copyright transfer agreement with your publisher or sponsor of your funding he can deny the article being published in open source website or journal.
The only surprise is that in future based on the new Law the Director of NIH can prevent publication by grant recipients in journals that don’t allow publications of articles into PubMed Central. Aha now thats not good news for scientists and many are not going to welcome it either
But how many would care NIH is not the lone sponsor of grants, and yes certainly none from healthcare/pharma companies would allow their articles be published at open source journals. that questions how helpful the law would become
There is certainly going to evoke multiple responses from everyone, wired magazine says its bad news for the science publishing industry, who’ve rallied against initiatives such as PRISM, and other open source websites such as PLOS, to preserve the right of journal publishers to charge for access to federally-funded findings. that means they will find their ways
Am certainly one of those not so politically obsessed persons, and I dont know that many politically savvy lab rats. may be few of those working in stem cell research, cloning or any other controversial topics might be. but I am beginning to like Dubya more. Not a bad a move for someone more associated bad grammar
Your Lab Data is a free web-based LIMS (Laboratory Information Management System), aimed at a typical small molecular biology laboratory. It allows users to manage their chemicals, fridges, freezers, boxes, strains, plasmids or glycerol’s, oligos / primers and much more.
Assay Depot is claiming to become an on-demand” drug discovery services. The company is has launched Internet marketplace for the pharmaceutical services industry. By acting as a single point of contact between drug researchers and research service providers, the Assay Depot dramatically improves the efficiency of drug discovery research and, ultimately, helps deliver better and safer drugs to market. By bringing the true benefits of outsourcing to the pharmaceutical industry
The San Diego company has raised $ 1.8M of funding from private finanical firms. CEO Kevin Lustig has also been the Co-Founder and Research Direcotr at Kalypsys
Microsoft launches Personal Healthcare Intiative -conversation with Peter Neupert VP of Microsoft’s Health Solutions Group about HealthVault
Microsoft announced HealthVault, an online platform where personal electronic health records can be stored.
The company’s consumer health offering includes a personal health record, as well as Internet search tailored for health queries, under the name Microsoft HealthVault www.healthvault.com
The organizations that have signed up for HealthVault projects with Microsoft include the American Heart Association, Johnson & Johnson LifeScan, NewYork-Presbyterian Hospital, the Mayo Clinic and MedStar Health,
Take a look at the conversation with Peter Neupert VP of Microsoft’s Health Solutions Group about HealthVault from the Channel9 MSDN