Rribozymes prevent the spread of HIV in the body

considered by some to be the ‘living fossils’ of a time when life was based on RNA -Rribozymes have been used by researchers to prevent the spread of HIV in the body

The Medical Marketing International Group (MMI) scientists have used these ancient RNA catalysts to suppress key receptors that allow HIV to enter cells

HIV enters cells using the cellular receptors CCR5 or CXCR4 and previous work has shown that preventing the expression of these receptors using the Company’s proprietary ribozymes, which target the messenger RNA (‘mRNA’) that encodes these proteins, is highly effective at preventing HIV replication in vitro. The results announced today show that the ribozyme technology can effectively deliver the ribozyme and suppress expression of these receptors in an advanced in vivo model. Moreover, a single administration of the ribozymes was able to maintain suppression of the receptors for a significant period (>35 days so far), indicating that a pool of HIV-resistant cells could be established.

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5 Responses

  1. So this would be a method of stabilizing the infection and not necessarily eliminating it, right?

    Great find, by the way.

  2. […] considered by some to be the living fossils of a time when life was based on RNA -Rribozymes have been used by researchers to prevent the spread of HIV in the body The Medical… …more […]

  3. […] considered by some to be the living fossils of a time when life was based on RNA -Rribozymes have been used by researchers to prevent the spread of HIV in the body The Medical… …more […]

  4. […] considered by some to be the living fossils of a time when life was based on RNA -Rribozymes have been used by researchers to prevent the spread of HIV in the body The Medical… …more […]

  5. Do these Rribosymes therefore act as antisense to the strands of messenger RNA that translate these key receptors CCR5 or CXCR4 and thus if this is the case why not prevent there transcription in the nucleus by binding to the region encoding these receptors and thus create a longer supression period or more over one that can be maintained until the virus in the latency period of an infected individual can be reached by overturning of the pool of memory cells where the virus resides?? Tamer Ismail St Georges Medical School London

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