Hormone-replacement therapy influences gene expression profiles and is associated with breast-cancer prognosis: a cohort study

source : http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1555602   Postmenopausal hormone-replacement therapy (HRT) increases breast-cancer risk. The influence of HRT on the biology of the primary tumor, however, is not well understood.   We obtained breast-cancer gene expression profiles using Affymetrix human genome U133A arrays. We examined the relationship between HRT-regulated gene profiles, tumor characteristics, and recurrence-free survival in 72 [...]

DNA microarray–based analysis may be useful for assessing the risks and benefits of hormone therapy

Hormone-replacement therapy influences gene expression profiles and is associated with breast-cancer prognosis. The US FDa has apprved use of two new microarrays for clinical decision making. The US Food and Drug Administration (FDA) encourages the development of new technologies such as microarrays which may improve and streamline assessments of safety and the effectiveness of medical [...]