Surface plasmon resonance (SPR) reflectivity measurements are surface-sensitive, spectroscopic methods that can be used to characterize the thickness and/or index of refraction of ultrathin organic and biopolymer films at gold, silver surfaces.
The probes can be proteins, peptides, nucleic acids, sugars, membranes, or any other molecule. GWC Technologies is one such company that offers the services in this field
SPR imaging detects the presence of a biopolymer on a chemically modified gold surface by the change in the local index of refraction that occurs upon adsorption.
Research Papers are on , Uiversity of California, Irvine page and also at
Filed under: Next Generation of DNA and RNA Microarrays, microarray
In my past career – I’ve done a ton of surface modification – thus requiring imaging/detection. It was/is never easy.
SPR, flourescence, quenching, IR, SERS….it just was always fickle.
PCR has such a stronghold. Maybe a few technologies will compete, but was the IP is generic….why not keep doing PCR. Flow methods will make it faster.